▕　Extracts from mycelial culture medium of Ganoderma lucidum (Ganoderma lucidum)　

MAK was developed in 1996 and is an extract produced by growing mycelia of Reishi (another name for Mannentake), which has been prized since ancient times in China, on a solid medium made from bagasse (a fibrous component of sugar cane) and defatted rice bran, based on a process of Shiitake mushroom mycelia culture medium extract.
MAK is characterized by the presence of unique and useful substances produced by the Ganoderma lucidum mycelium as it metabolizes and grows on the bagasse and rice bran in the culture medium.
 

▕　Bioactive components of MAK and their actions　

Like LEM, MAK contains two types of active components, heteropolysaccharides and water-soluble lignin, both of which are produced by enzymes in the mycelium of the mycelium of Astragalus membranaceus, which also produces enzymes not found in the mycelium of shiitake mushroom. Heteropolysaccharides are composed mainly of pentasaccharides such as arabinose and xylose and hexasaccharides such as glucose. MAK also has a variety of actions, including antioxidant, brain damage protective, blood sugar elevation inhibitory, blood pressure elevation inhibitory, immunomodulatory, antiviral, and mood disorder ameliorating actions.
 

▕　Safety of MAK

The mycelium used in the production of MAK is the same as that of the edible mannentake mushroom. Therefore, there are no safety issues. The safety of MAK has been confirmed through various safety tests, including toxicity and mutagenicity tests, conducted by an analytical laboratory.

 ▕　Examples of MAK Effectiveness Tests　

 
▒ Antioxidant action
The 50% inhibitory concentration (ICso) was calculated for two antioxidant activities of MAK: O2 (superoxide anion) scavenging capacity and inhibition of lipid peroxide production. The results showed that MAK had antioxidant capacity comparable to that of vitamin C and vitamin E.
 
▒ Brain cell protective effects
Type I diabetic mice were divided into three groups: one group received MAK (0.3 or 1 g/kg) dissolved in distilled water orally and the other group received distilled water only. Administration was done once a day for 7 days. Half of the brains were then treated with hypoxia and observed for brain cell protection. The results showed that the formation of cerebral infarcts was inhibited in the MAK-treated group. In particular, the inhibitory effect was particularly high in the 1 g/kg dose group.